منابع مشابه
Nonviral gene transfer to the liver.
2. Bismuth H, Chiche L, Adam R, Castaing G. Liver resection versus transvant issue. First-generation recombinant adenoviruses have plantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg associated toxicity, particularly immunogenicity resulting in 1993;218:145-151. inflammation of transduced tissues in vivo. Recent improve3. Iwatsuki S, Starzl T, Sheahan D, Yokoyama I, Demetris...
متن کاملNonviral gene delivery to the liver
Diseases of the liver have a large impact on human health. Genetic disorders, metabolic disorders, alcoholism, cancer, or infections can all impair liver function. If serious enough, a liver transplant may be necessary, a major surgical procedure which requires life-long immune suppression and relies on the availability of donor livers. Gene therapy is being intensively studied as a potential m...
متن کاملEfficacy of nonviral gene transfer in the canine brain.
OBJECT The purpose of this study was to evaluate the gene transfer capability and tolerability of plasmid DNA/polyethylenimine (PEI) complexes in comparison with adenovirus and naked plasmid DNA in the canine brain. METHODS Plasmid or adenoviral vectors encoding firefly luciferase were injected directly into the cerebral parenchyma of five adult dogs at varying doses and volumes. Serial physi...
متن کاملAnalysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system.
The aim of the present study was to evaluate the efficacy of novel nonviral gene delivery systems in cells of musculoskeletal origin. Primary cultures of lapine skeletal muscle cells, lapine articular chondrocytes, human cells from fibrous dysplasia and cell lines established from human osteosarcoma (SAOS-2), chondrosarcoma (CS-1), murine skeletal myoblasts (L8) and fibroblasts (NIH 3T3) were t...
متن کاملPerinatal Gene Transfer to the Liver
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases can be managed using conventional medicines whereas others are, as yet, untreata...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1996
ISSN: 0270-9139
DOI: 10.1053/jhep.1996.v24.ajhep0241541